In 1941, Anne Frank’s had left Germany for the Netherlands and was trying to escape to America. Her father Otto Frank wrote to a college friend living there asking for help and money to cover the deposit for their visas:
I am forced to look out for emigration and as far as I can see U.S.A. is the only country we could go to … Perhaps you remember that we have two girls. It is for the sake of the children mainly that we have to care for. Our own fate is of less importance.
Because of tightening restrictions on refugees from Europe, pushed in part by hardening anti-foreigner sentiment in America, Otto was unable to secure visas for his family. They went into hiding in 1942.
Anne, her sister, and mother later died in concentration camps.